Calgary Health Foundation

$150,000 investment in the AB-HOPE COVID-19 Trial

Thanks to our generous donors, Calgary Health Foundation is extremely proud to invest $150,000 in this innovative study through our Clean Hands, Giving Hearts COVID-19 Response Fund.

University of Calgary and University of Alberta researchers are leading a province-wide study to investigate the effectiveness of the well-tolerated drug hydroxychloroquine (HCQ) as an early intervention for Albertans who test positive for COVID-19. Treatment options for COVID-19 are unclear and research is critical to find new avenues to help people battle the virus. 

With support from Alberta Health Services Strategic Clinical Networks, and the Government of Alberta the randomized, double-blind, placebo-controlled clinical trial, Alberta HOPE COVID-19, will recruit over 1600 Albertans who have recently tested positive for COVID-19 to determine whether a prescribed five-day treatment of HCQ can prevent hospitalization for those at highest risk of developing a severe illness. 

“We will be targeting Albertans who have an underlying medical condition which has proven to contribute to the worsening of symptoms, and eventual hospitalization,” says Dr. Luanne Metz, MD, principal investigator on the study, acting facility medical director, Foothills Medical Centre, and professor at the Cumming School of Medicine (CSM). “Managing Albertans entirely in the community will ensure that hospital resources are available for those who are severely ill and others who require medical attention for conditions other than COVID 19.” 

The study will recruit Albertans who are at home, can swallow a pill and can begin the treatment protocol within 96 hours of testing positive for the SARS-CoV-2, the virus that causes COVID-19. They also have to be within a 12-day window of the first reported symptoms of the virus.

“Alberta HOPE COVID-19 is an Alberta-only unique trial, designed, run and funded in Alberta,” says Dr. Michael Hill, MD, study co-lead in Calgary and professor at the CSM. “The clinical trials team at the university and AHS are highly experienced and dedicated to this effort, thanks to our proven experience we were able to get this trial up and running at an unprecedented pace.”

 Dr. Luanne Metz, MD, principal investigator on the study and Dr. Michael Hill, MD, study co-lead


The drug and placebo for the trial are being donated by Canadian manufacturer, Apotex. HCQ is originally an anti-malarial drug currently used mostly for immunological disorders like rheumatoid arthritis. Laboratory studies also suggest that it may be helpful against the COVID-19 virus, however, there have only been very small studies suggesting clinical benefit. 

“Clinical trials like this will give healthcare professionals more evidence to determine how best to care for patients,” says Dr. Kathryn Todd, PhD, AHS Vice President Provincial Clinical Excellence. “AHS is rallying alongside its academic partners at the Universities of Calgary and Alberta to help leverage research in the response to this global pandemic.” 

Staff from Alberta Health Services will obtain permission from individuals with positive COVID-19 tests to provide their contact information to the researchers. Consenting participants will be screened for safety and eligibility. The treatment will then be delivered to their door, anywhere in Alberta. Receipt of the treatment will be witnessed by the courier and confirmed by phone. Participants will then be followed up by phone on day seven and day 30 of starting the treatment. 

The study is supported by Calgary Health Foundation, Alberta Innovates, the Government of Alberta and the University of Calgary/Alberta Health Services Clinical Research Fund. 

Researchers are seeking approval to ask participants in the Alberta HOPE COVID-19 trial whether other household members, who have not tested positive for COVID-19, may be interested in joining a different research study. U of A researchers, Dr. Lawrence Richer, MD, and Dr. Ilan Schwartz, MD, PhD are investigating whether HCQ may be effective in slowing or even preventing the transmission of COVID-19. 

“This prevention trial is for people who are exposed to somebody infected with COVID-19,” says Schwartz, an infectious disease specialist and U of A site-lead for the clinical trial. “Eligible participants will be adults - who don't have symptoms and have not tested positive for COVID-19 - who live with someone diagnosed with COVID-19, and healthcare workers who have exposure to known cases.” That study will look at whether the medication, when administered within a few days of a person’s first exposure, can prevent infection from occurring and whether it can prevent progression to a disease requiring hospitalization. Half the participants will receive HQC the other half will receive a placebo. 

To find out more about these studies and other research projects related to COVID-19 that you can participate in check out the Be the Cure website.